A YOUNG woman saw nearly a third of her skin peel away in sheets just days after starting a new medication.
The 24-year-old had been prescribed , a commonly used on the NHS to treat mood disorders and .
But just days after starting the medication to treat her , she noticed a spreading rapidly across her body.
By day four she decided to head to the hospital after the marks started blistering and large areas of skin started falling off.
Doctors treating her at Cheikh Khalifa International University Hospital in Morocco quickly diagnosed her with Lyell’s syndrome, also known as toxic epidermal necrolysis (TEN).
This is a rare but life-threatening reaction to a – which in this case was lamotrigine. But it has also been associated with , and anti-inflammatorylike.
It happens when the body overreacts to a drug causing the outer layer of skin, known as the epidermis, to detach and peel away in sheets, exposing the raw, sensitive tissue beneath.
survivors of the condition have described the experience as feeling like they were being ‘burned from the inside out’ or ‘cooked alive, due to the intense pain and widespread skin loss it triggers.
In worst-case scenarios, it can leave those affected vulnerable to life-threatening complications like and organ failure – it carries a mortality rate between 20 and 40 per cent.
In this case, published as part of a report in the journal Cureus, almost 30 per cent of her body surface area had been affected including her chest, back, arms, and thighs.
Large sections of skin had already sloughed off by the time she arrived at hospital, leaving painful, exposed areas that had to be treated like serious burns.
Doctors also noted that her mucous membranes were involved, meaning the reaction had affected not just her skin but also the inside of her mouth and genitals, a common but dangerous feature of TEN.
Once admitted, the unidentified woman was transferred to a specialist burns unit, as TEN causes skin damage similar to that seen in people with major burn injuries.
“TEN is often described as a severe burn-like skin reaction because it causes widespread epidermal necrosis and detachment similar to that seen in patients with extensive burns,”;; the authors of the report wrote.
After intensive treatment in the burns unit including wound care, pain relief, and fluid replacement she began to recover.
Doctors immediately stopped the lamotrigine to prevent further skin damage and prescribed another medication to manage her bipolar disorder safely.
The authors stressed that while TEN is a rare reaction, patients starting drugs like lamotrigine should be monitored closely for early symptoms such as fever, rash, and blistering.
“The early recognition and discontinuation of the offending drug is crucial in improving patient outcomes,”;; they concluded.
