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Struggle to fall asleep or feel tired all the time? You could be at risk of early death from ‘circadian syndrome’

Published on April 30, 2025 at 01:59 PM

DIFFICULTY falling asleep, staying asleep, and daytime sleepiness could mean you’re at risk of early death from circadian syndrome (CircS), say scientists.

CircS isa concept that links a cluster of chronic conditions to disruptions in the body’s natural circadian rhythm, which regulates sleep-wake cycles and other bodily functions.

Man lying in bed looking distressed.
Circadian rhythm imbalances, also known as sleep-wake cycle disorders, can result in difficulty falling asleep, staying asleep, or waking up at desired times

It’s suggested that imbalances in a person’s circadian rhythm can contribute to the development of conditions like , hypertension, type 2 , , and disorders.

Circadian rhythm imbalances, also known as sleep-wake cycle disorders, can result in , staying asleep, or waking up at desired times, as well as feeling tired all the time (TATT).

In a new study, middle-aged adults suffering .

As part of the research, Chinese and American participants were considered to have CircS if they reported at least four of seven components – hypertriglyceridemia, central , low high-density lipoprotein (HDL) , , hyperglycemia, sleep deprivation (defined as less than six hours), and depressive symptoms.

Of the 7,637 Chinese participants that took part, 2,270 had CircS, and 4,335 out of the 9,320 American participants had the condition.

Among both the Chinese and American participants, those with CircS were older and had higher rates of chronic diseases, including , hypertension and diabetes.

The Chinese participants were followed up after 9.17 years, and 142 deaths occurred, with mortality rates higher in the CircS group.

In the American cohort, in over a mean of 7.4 years 1,321 deaths were recorded, with higher mortality also found in the CircS group.

Key CircS components like large waist circumference, depression, diabetes, and hypertension were individually linked to increased mortality.

In the American cohort, CircS was significantly associated with multiple specific causes of death, including heart disease, diabetes, kidney disease, , malignant neoplasms, and infections such as and .

The study authors concluded CircS is a modifiable cluster of risk factors linked to increased mortality.

Also, that early detection and lifestyle interventions targeting CircS components could significantly reduce disease burden and mortality in middle-aged and older adults.

Circadian rhythm imbalances can stem from a variety of factors, includinglifestyle choices, environmental influences, and even underlying medical conditions.

Inconsistent sleep schedules, staying up late, and exposure to artificial light at night can disrupt your body’s natural clock.

Working irregular hours, especially , can disrupt your sleep-wake cycle and make it difficult to align with your body’s natural rhythms.

Insufficient exposure to sunlight during the day can weaken your circadian system’s synchronisation with the environment.

And , chronic caffeine use, and illegal can interfere with sleep and circadian rhythms.

To help reset your circadian rhythm try the following tips below...

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