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Warning over brutal & ‘super common’ Ozempic side effect that happens ‘overnight’ & makes users look ‘20 years older’

Published on May 05, 2025 at 07:08 AM

NAUSEA, constipation, breathing problems, racing heart... the list of Ozempic side effects appears to be growing by the day.

And now experts have revealed a new “incredibly common”; issue that “nearly everyone”; using will experience.

Gemma Collins and Rebel Wilson posing together backstage.
Celebrities including Gemma Collins and Rebel Wilson have proudly confessed to using skinny jabs to shed the pounds
Person injecting Ozempic.
But now there’s a ‘super common’ side effect of the weight loss medication

TOWIE’s used fat jabs to shed two stone and has admitted to noticing this unwanted, near-instant effect, which some professionals say makes you look “20 years older”;.

The term ‘Ozempic lines’ refers to the deep facial wrinkles that can appear when someone loses a significant amount of weight quickly after using , including Ozempic, Mounjaro and Wegovy.

icon Gemma, 44, exclusively told The Sun she’s been using the NHS-approved drug Mounjaro since November

But , Gemma is convinced her face is at an increased rate, with deep lines appearing out of nowhere.

‘Happened overnight’

Last week, she wrote on social media: “I really don’t know what’s happened to me, I really don’t. It’s just come on me overnight. But it has been a year since I’ve had any little tweakments.

“I don’t know if it’s since I’ve been losing weight. I sure haven’t got ‘Ozempic face’ yet, but it would be the dream right now.

“I’ve always had a fuller face, as you know. I do have expression around my eyes. I want to look natural still.

“But this just isn’t right. What has happened? I am 44 but this is taking it to levels that I never, ever imagined it’d get to.”;

‘Super common’

Dr Ed Robinson, one of the UK’s leading aesthetic doctors, told Fabulous that ‘Ozempic lines’ are an issue many of his patients are experiencing.

He said: “With such rapid weight loss, we’re increasingly seeing aesthetic side effects.

“‘Ozempic lines’ are the fine lines and deeper wrinkles that can appear when someone loses a significant amount of weight quickly – often after using weight-loss medications like Ozempic.

“It’s super common because when the face loses volume, particularly fat, that once provided natural plumpness, the skin can start to sag, wrinkle, and look more hollow.

“We also see a reduction in proteins collagen and elastin which can lead to crepiness of the skin, most noticeably around the eyes and mouth.

“Without the natural support from underlying fat, both the face and neck can appear aged, saggy, and out of balance.”;

has quickly become as famous as .

The medication, originally intended for sufferers, has now hit headlines around the world for how quickly it allows people to .

It’s become the poster child for a new wave of that can help people drop up to a fifth of their but other brands such as Mounjaro, Wegovy and Zepbound have also gained traction.

Gemma Collins on holiday in a pink swimsuit.
Gemma Collins, pictured here before using Ozempic, has lost two stone on fat jabs
Gemma Collins expressing concern about her appearance after weight loss injections.
Gemma, pictured here after her weight loss, noticed an “overnight”; change on her face

The , which have been called a “miracle”; by some, work by mimicking GLP-1, a hormone released in the body when we are full.

While many celebrities, including , 43, and , 72, have lost huge amounts of weight and openly talked about using Ozempic, there’s now a huge list of potentially negative side effects that we’re learning more about.

These weight loss medications can rapidly add 10 to 20 years to a once plump, youthful face such as Gemma’s

Gerard Lambe

‘’ and ‘’ are other conditions that aesthetic doctors have commented on.

But it’s ‘Ozempic lines’ that are the current plight of jab users.

Gerard Lambe, one of the UK’s leading consultant cosmetic surgeons, who heads up the Reflect Clinic, told Fabulous Gemma’s “skin changes are incredibly common”;.

‘Accelerated ageing’

He said: “‘Ozempic lines’ are basically the accelerated ageing and dehydration of the facial skin that appear within weeks of starting the jabs and it’s unfortunately one of the prices anyone using these peptides has to pay.

“Nearly everyone who is on Ozempic and has had significant has seen a negative .

“These weight loss medications can rapidly add 10 to 20 years to a once plump, youthful face such as Gemma’s.”;

Gerard, who regularly carries out on people who have experienced major weight loss, claims Ozempic users have noticed an increase in facial lines after short term use.

He said: “Many women come to me panicking that they have aged overnight, or certainly in weeks, just like Gemma, following weight loss jab use.

“With Ozempic and Mounjaro, various changes are happening that create serious issues with skin elasticity and texture.

“Often, those using these injections lose their so swiftly they simply don’t eat enough or they eat very little and it is often low on nutrients.

‘Very worrying’

“The skin, especially facial skin, needs loads of protein and healthy fats to stay plump and smooth.

“Another major risk with these peptides is dehydration. It is silently and rapidly ageing the skin.

“As appetite drops so does the natural impulse to keep drinking fluids. I see this so often and it is very worrying.”;

Practitioners have noticed a rise in ‘Ozempic lines’.

Dr Robinson told us: “I am seeing these complaints much more frequently,”; while Dr. Omar Tillo added: “I’m seeing this more and more in the clinic lately, and it’s something most people notice after a big weight drop. It’s not unusual.”;

But can this worrying side effect be combated?

Gerard explains: “Investing in a good and avoiding the sun is going to help but will not reverse deep wrinkles and lines.”;

Additionally, he suggests: “Also make sure you commit to carrying a two litre water bottle everywhere and making a commitment to keeping her skin and super-hydrated.”;

But Gemma isn’t the only to have noticed a drastic change in her face after using weight loss jabs.

, who admitted to injecting herself with the in order to shed 42 pounds, has also discussed the implications the jabs have had on her face.

Speaking to Daily Mail, the 72-year-old Celebrity star said: “I don’t care what people say about the way I look.

I’m too gaunt and I can’t put any weight on

Sharon Osbourne

“I know I look gaunt and I know everything that goes along with it. And I did it.

“I’m too gaunt and I can’t put any weight on. I want to, because I feel I’m too skinny. I’m under 100lb and I don’t want to be. Be careful what you wish for.”;

Reflecting further on her experience on in November 2023, Sharon claimed she “could do with putting on a few pounds”; as she issued a stark warning about the injections.

Speaking to hosts and , Sharon warned: “I fear for , I’m scared for those aged 16 to 20 as it’s so easy to take it and think, ‘I can eat what I want’.

“It needs to be in the hands of only people who totally understand it.”;

Sharon Osbourne at the Billy Morrison - Aude Somnia Solo Exhibition.
Sharon Osbourne, pictured here in 2017, prior to her weight loss
Sharon Osbourne at the Los Angeles premiere of The Bikeriders.
Now, she has described herself as looking “gaunt”;

Meanwhile, fans have been left concerned that 41-year-old reality TV star , who shares three children with his ex , is looking incredibly gaunt after recently made a cameo on .

On an episode of the Hulu reality series, , 40, was sitting with , 29, when they called Scott to share a bit of news.

During a FaceTime call with the father-of-three, Khloe asked: “Did you see from the show? Did you see what’s in your fridge?”;

To this, a confused-looking Scott replied: “No?”;, however it doesn’t take long for him to clock on to what Khloe was subtly trying to say.

“No! It shows the Mounjaro? You’re lying”;, he added.

And now, an insider revealed all to Daily Mail about Scott’s new gaunt appearance.

Scott Disick at the premiere of Hulu's
Scott Disick, snapped here in 2022, has admitted to using Mounjaro
Scott Disick in a video, appearing concerned.
Fans previously expressed concern over his ‘sunken eyes and cheeks’

The source shared: “Scott recognised that he needed to stop taking Ozempic after seeing the photos of himself and the public outcry over his weight loss.

“He thought he looked good because he was thinner again – not realising that this was not healthy.

“He is now working with a nutritionist to get back on track and not balloon up to the size he was.

“Scott has been incredibly attractive and fit his entire life and is not having the best time accepting that age is catching up with him.”;

Whoopi Goldberg backstage at a Broadway play.
Whoopi Goldberg has also used Mounjaro for weight loss
Rebel Wilson at the Zurich Film Festival.
Rebel Wilson is another celeb to have used fat jabs to slim down

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